MersV1, Main, Exploration, bibRecord, 004A55

Toxicity of, and histological lesions caused by, ribosome‐inactivating proteins, their IgG‐conjugates, and their homopolymers

Identifieur interne : 004A55 ( Main/Exploration ); précédent : 004A54; suivant : 004A56

Toxicity of, and histological lesions caused by, ribosome‐inactivating proteins, their IgG‐conjugates, and their homopolymers

Auteurs : Maria Giulia Battelli [Italie] ; Luigi Barbieri [Italie] ; Fiorenzo Stirpe [Italie]

Source :

APMIS [ 0903-4641 ] ; 1990-07.

RBID : ISTEX:EB2442E442F38C2A2A3E329C6E499A0F75425DD5

English descriptors

Teeft :
- Activity units, Barbieri, Biochem, Bryodin, Conjugation, Conjugation reaction, Derivatized, Derivatized rips, Dos, Eukaryotic ribosomes, Experimental details, Final concentration, Free rips, Gelonin, Gelonin homopolymers, Histological, Histological changes, Histological lesions, Homopolymers, Immunotoxins, Immunotoxins table, Inhibitory activity, Iodogen reagent, Lesion, Lethal doses, Lower doses, Lysate, Main lesion, Molar ratio, Molecular weight conjugate, Molecular weight conjugates, Momordin, Monoclonal antibody, Necrotic lesions, Patologia sperimentale, Plant proteins, Protein synthesis, Proteins rips, Rabbit reticulocyte lysate, Rabbit reticulocyte lysate reaction mixture, Rabbit reticulocytes, Reticulocyte, Ribosome, Rip, Rips type, Room temperature, Saponaria oflcinalis, Saporin, Sephacryl superfine column, Spdp, Stirpe, Toxic lectins, Toxicity, Toxin, Weight conjugate, Weight homopolymers.

Abstract

The toxicity of, and the lesions brought about by, several ribosome‐inactivating proteins (bryodin, gelonin, momordin, pokeweed antiviral protein from seeds, saporin 6, trichokirin and momorcochin‐S), either native, or conjugated to bovine IgG, or polymerized, were studied in the mouse. Severe necrotic liver damage was the main lesion present in animals receiving lethal doses of the proteins. The toxicity of ribosome‐inactivating proteins increased after conjugation to IgG or homopolymerization. The toxicity of conjugates to mouse was not predictable from the inhibitory activity on cell‐free protein synthesis.

Url:

https://api.istex.fr/ark:/67375/WNG-6DGFT2S0-F/fulltext.pdf

DOI: 10.1111/j.1699-0463.1990.tb04975.x

Affiliations:

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Le document en format XML

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<term>Conjugation</term>
<term>Conjugation reaction</term>
<term>Derivatized</term>
<term>Derivatized rips</term>
<term>Dos</term>
<term>Eukaryotic ribosomes</term>
<term>Experimental details</term>
<term>Final concentration</term>
<term>Free rips</term>
<term>Gelonin</term>
<term>Gelonin homopolymers</term>
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<term>Iodogen reagent</term>
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<term>Lethal doses</term>
<term>Lower doses</term>
<term>Lysate</term>
<term>Main lesion</term>
<term>Molar ratio</term>
<term>Molecular weight conjugate</term>
<term>Molecular weight conjugates</term>
<term>Momordin</term>
<term>Monoclonal antibody</term>
<term>Necrotic lesions</term>
<term>Patologia sperimentale</term>
<term>Plant proteins</term>
<term>Protein synthesis</term>
<term>Proteins rips</term>
<term>Rabbit reticulocyte lysate</term>
<term>Rabbit reticulocyte lysate reaction mixture</term>
<term>Rabbit reticulocytes</term>
<term>Reticulocyte</term>
<term>Ribosome</term>
<term>Rip</term>
<term>Rips type</term>
<term>Room temperature</term>
<term>Saponaria oflcinalis</term>
<term>Saporin</term>
<term>Sephacryl superfine column</term>
<term>Spdp</term>
<term>Stirpe</term>
<term>Toxic lectins</term>
<term>Toxicity</term>
<term>Toxin</term>
<term>Weight conjugate</term>
<term>Weight homopolymers</term>
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<front><div type="abstract" xml:lang="en">The toxicity of, and the lesions brought about by, several ribosome‐inactivating proteins (bryodin, gelonin, momordin, pokeweed antiviral protein from seeds, saporin 6, trichokirin and momorcochin‐S), either native, or conjugated to bovine IgG, or polymerized, were studied in the mouse. Severe necrotic liver damage was the main lesion present in animals receiving lethal doses of the proteins. The toxicity of ribosome‐inactivating proteins increased after conjugation to IgG or homopolymerization. The toxicity of conjugates to mouse was not predictable from the inhibitory activity on cell‐free protein synthesis.</div>
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Toxicity of, and histological lesions caused by, ribosome‐inactivating proteins, their IgG‐conjugates, and their homopolymers

Toxicity of, and histological lesions caused by, ribosome‐inactivating proteins, their IgG‐conjugates, and their homopolymers

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri